International Journals of Multidisciplinary
Research Academy (IJMRA)

Abstract:
Micro RNAs (miRNAs), a class of endogenous small non-coding RNAs in eukaryotes that regulate cellular transcriptome at the post-transcriptional level has been recognized. More than 2000 miRNAs have been identified in the human genomes that have orchestrated a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multi-factorial metabolic disorder affecting large number of people worldwide. MiRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. The altered miRNAs are involved in the core processes associated with diabetes such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This dysregulated miRNAs in different tissues during development of diabetes provides molecular insights to diagnostic and/or therapeutic utilities in diabetes mellitus. In this review, the investigations of the regulatory roles of important miRNAs in pancreas has been discussed that can be used to treat diabetes mellitus.
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Abstract:
In this paper, Cosine logarithmic distance among single valued neutrosophic sets is proposed and some of its properties are discussed herein. Finally, an application of medical diagnosis is presented to find out the disease impacting the patient. Download full Lenght Paper......

Abstract:
A primary goal of seismic provisions in building codes is to protect life safety through prevention of structural collapse. To achieve this goal major factors, which results in uncertainties of the structural responses should be recognized. Uncertainty is generally costly in earthquake engineering because of the large amount of the parameters that should be considered for its calculation. Endurance time method is basically a dynamic procedure that tries to predict seismic performance of structures by analyzing their resilience when subjected to predesigned intensifying dynamic excitations Download full Lenght Paper......

Abstract:
The aim of this paper is to introduce the new class of intuitionistic fuzzy closed sets called intuitionistic fuzzy rgw-closed sets in intuitionistic fuzzy topological space. The class of all intuitionistic fuzzy rgw-closed sets lies between the class of all intuitionistic fuzzy swg-closed sets and class of all intuitionistic fuzzy rwg-closed sets. We also introduce the concepts of intuitionistic fuzzy rgw- open sets, intuitionistic fuzzy rgw-continuous mappings in intuitionistic fuzzy topological spaces. Download full Lenght Paper......

Abstract:
In drinking water concentration of fluoride should be in requisite amount, excess amount of fluoride in drinking water causes dental fluorosis, mottling of teeth. while less concentration of fluoride in ground water results in a high incidence of dental caries, in children’s teeth. Satna district is famous for dolomite mines and limestone, fluoride ions dissolved in ground water from geological formations, so it becomes very important to analysis the fluoride in water of bore-wells for used drinking purpose in Satna city, in this analysis evaluation of fluoride concentration done by standard analytical procedures and found 0.79 to 0.689 ppm at different sampling station of Satna city during November 2017 to April 2018. Download full Lenght Paper......

Abstract:
Phytochemicals are plant-derived secondary metabolites, which may exert many biological activities in humans, including anticancer properties. Although recent findings appear to support their role in cancer prevention and treatment, this issue is still controversial. Anti-cancer activity of phytochemicals mainly depends on their multi-target mechanism of action, including antimutagenic, antioxidant and antiproliferative activities. This narrative review aims to analyze the current literature on phytochemicals highlighting their specific targets on carcinogenic molecular pathways and their chemopreventive role.Phytochemicals can contribute to cancer prevention by influencing different stages of the tumor development, from tumor initiation through all the phases of cancer, such as cell proliferation, apoptosis, invasion and metastasis, angiogenesis and immortality. This research article discuss on impact of plants derived for anticancer phytochemicals and its importance. Download full Lenght Paper......

Abstract:
In this particular work we discuss about classes of macrocycles, overall qualities, various kinds of artificial methods, possible applications as well as the pioneering work extracted from various opinions, hundreds and articles huge selection of research publications described by different eminent chemists throughout the earth during past several years. The continued efforts of chemists to proliferate this chemistry are not just because of structural novelties of the compounds but additionally as a result of diverse applications of theirs. Therefore, the hassle embodied in this specific analysis is going to designed the synthesis and physico chemic studies of macrocyclic and the complexes of theirs with initial row transition metal ions Mn(II) Fe(ll) Co(II), Ni(II) and Zn(II) through organic and template strategies showing new structural abilities. Some of the complexes will likely be examined for antimicrobial pursuits. Download full Lenght Paper......

Abstract:
The tooth is the only mineralized organ that is located partially internal and partially external to the human body. From materials science point of view, a tooth is a composite material with mineralized matrix and organic reinforcements. Human teeth act as a mechanical device during masticatory processes such as cutting,tearing and grinding of food particles. Its mechanical properties are due to its mineral composition and structural arrangement. A calcium phosphate apatite is the basic constituent of the enamel, typically as hydroxyapatite forms. The enamel mineral matrix of teeth is usually named as enamel apatite (EAP) or carbonated hydroxyapatite. The mineral phase consists primarily of calcium phosphate in the form of large hexagonal hydroxyapatite crystals that are both carbonated and defective. Human tooth is composed of three basic structural parts, namely enamel, dentine and dentine-enamel junction (DEJ) which has been characterized in terms of microstructure, phase analysis and compositional gradient. It has been observed that microindentation hardness varies from enamel to dentine with the highest hardness observed for enamel at the outermost surface (around 3.5GPa). Hardness values monotonically decreases with depth to less than 1GPa, measured at the interior dentine. Such a variation depends partially upon the mineral concentration in enamel and dentine, with a possible dependence also on local microstructural features such as enamel rod orientation and dentinal tubule density. Furthermore, the measured hardness variation is found to have a noticeable correlation with the compositional variation. Download full Lenght Paper......

Abstract:
In recent years, the development of efficient green chemistry methods for synthesis of metal nanoparticles has become the main focus of researchers. They have investigated in order to find outan eco- friendly technique for production of well-characterised nanoparticles. One of the most considered methods is production of metal nanoparticles using plant parts extracts. Nanoparticles produced by plants are more stable and the rate of synthesis is faster than in the case of microorganisms. Moreover, the nanoparticles are more various in shape and size in comparison with those produced by microorganisms. The present paper deals with the synthesis of copper nanoparticles by a simple procedure using papaya leaf extract as the reducing agent. This procedure offers control over the size of the copper nanoparticles. The nanoparticles produced in this way were characterised by various techniques Download full Lenght Paper......

Abstract:
The creating scene is horribly not ready for the new innovative and financial open doors, difficulties and dangers that lie not too far off. Despite the fact that it is trusted that biotechnology will work on the existence of each and every individual on the planet and permit more maintainable living, pivotal choices might be directed by business contemplations and the financial objectives that society views as the most significant. Around the world, domesticated animals creation is becoming quicker than some other area, and by 2020 animals is anticipated to turn into the main farming area regarding added esteem. The utilization of biotechnology will prompt a particular change in the monetary gets back from domesticated animals Download full Lenght Paper......

Abstract:
Let A a  n k,  be an infinite matrix of complex numbers a nk nk  1,2,3,........ and let  n  be a sequence of complex numbers. Let n a be a given infinite series with the sequence of partial sums sn  . By A s n  we denote the A - transform of the sequence s s   k  , that is   1 n nk k k A s a s    The series n a is said to be Summable A , if   1   1 n n n A s A s       And it is said to be Summable 1 k    A k , if   1   1 [ ] , n n n n  A s A s k       If we take 1 1 k n  n      1 1 , 0 k n resp n         , Then k   A Summability is the same as k K A resp A Summability. Download full Lenght Paper......

Abstract:
The purpose of present work was to study the influence of Ethylene glycol on CoO catalysed autoxidation of S(IV) in alkaline medium has been studied for acidified atmospheric water. Based on the observed results and inhibition parameters following rate law and free radical mechanism has been proposed. The order of the reaction and rate constants were calculated and the reaction was found to be pseudo first order in all case. The effect of temperature and pH are also discussed. We report that Ethylene glycol is a good inhibitor for SO2 Oxidation in the pH range 7.5 to 8.50..The value of apparent activation energy (Ea) was given by Arrhenius equation (K= A .e-Ea/Rt). -d[S(IV)] = (k1 +k2 [CoO]) [S(IV)] dt 1+ B [E.G] Download full Lenght Paper......

Abstract:
he main objective is to investigate interactions in a non localthermoelastic medium with gravityunderLord-Shulman theory. The mechanical load is applied at the outer free surface of the half-space to obtain the complete solution of the physical field distributions.By employing the normal mode technique, the analytical expressions for the displacement components, stresses and temperature are obtained in the physical domain. The comparisons are made among the results obtained by taking into account the effect of gravity and the different values of nonlocal parameter. Theoretical and numerical findings show that the physical variables under consideration are significantly influenced by the nonlocal parameter and gravity field. All physical fields maintain the phenomena of the finite speed of propagation which is consistent with the generalized theory of thermoelasticity. Download full Lenght Paper......